EXPLORATION OF THE IMMUNOGENETIC LANDSCAPE OF HYPERPROGRESSIVE DISEASE AFTER COMBINED IMMUNOTHERAPY IN CANCER PATIENTS

Exploration of the immunogenetic landscape of hyperprogressive disease after combined immunotherapy in cancer patients

Summary: The immune-genetic changes that occur in cancer patients experiencing hyperprogressive disease (HPD) during combined immunotherapy are unclear.In this study, HPD patients with donjoy iceman shoulder wrap pre- and post-HPD samples and non-HPD patients with solid tumors were molecularly characterized by genetic and tumor immune microenvironm

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Study of Topical Human Umbilical Cord Blood Serum in the Treatment of Alkaline Corneal Epithelial Wounds in Rabbit Model

Introduction & Objective: One of the important functions of the cornea is to maintain normal vision by refracting light onto the lens and retina.This property is dependent in part on the ability of the corneal epithelium to undergo continuous renewal.Ocular surface failure which follows a variety of endogenous and exogenous precipitating factors, 4

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Effect of Different Primings on Germination and Growth Parameters of Rice (Oryza sativa) Seeds during Drought Stress, as Compared with Silver Nanoparticles

The present study sought to compare the effect of seed priming by hydropriming, ascorbate and calcium chloride (CaCl2) versus different concentrations of silver nanoparticles on two Iranian rice cultivars (Hashemi and Shiroodi) under drought stress.The experimental design, rock cliff reservoir which was factorial, was completely randomized.The firs

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ORM1 mediates osteoblast/osteoclast crosstalk in adolescent idiopathic scoliosis via RANKL/OPG ratio alteration

Adolescent idiopathic scoliosis (AIS), a complex early-onset three-dimensional spinal deformity, remains etiologically ambiguous despite extensive ongoing investigations.Currently, braces and surgeries are primary treatments of AIS, which come with inherent risks and costs.Therefore, there is an urgent need for biotherapeutic targets for AIS.Using

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